Hainsworth Shin, Ph.D.

Assistant Professor

Research Areas: Cellular Mechanotransduction

University of Kentucky, College of Engineering
Biomedical Engineering - BME
514D RMB
Lexington, KY 40506-0108
Phone: 859-257-3783
Fax: 859-257-1856
Email: hy.shin@uky.edu


Professional Preparation

B.S., Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, 1992
M.S., Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, 1995
Ph.D, Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, 2003

Appointments

Faculty, Engineering Platforms for Exploring Cellular and Molecualr Signaling Processes, KY-EPSCoR-Bioengineering Initiative, 2009 – present
Faculty, Sibu and Becky Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, KY, 2008 – present
Faculty, Engineered Bioactive Interfaces-Research Experiences for Undergraduates, 2008 – present
Faculty, Engineered Bioactive Interfaces-Integrated Graduate Education and Research Traineeship, 2008 – present
Peer-Reviewer, Bioengineering and Imaging Study Section, American Heart Association-Great Rivers Affiliate, 2008 – present
Assistant Professor, Center for Biomedical Engineering, University of Kentucky, Lexington, KY, 2007 – present
Ruth L. Kirschstein Postdoctoral Fellow, Department of Bioengineering, University of California-San Diego, La Jolla, CA, 2003 – 2007
Research Assistant, Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, 2002 – 2002
Research Assistant, Department of Cardiovascular Research, Genentech Incorporated, South San Francisco, CA. (employed through Adecco, South San Francisco, CA), 1999 – 2001
Research Intern, Department of Cardiovascular Research, Genentech Incorporated, South San Francisco, CA, 1999 – 1999

 

Recent Publications

  • Makino, A; Shin, HY; Komai; Y, Fukuda, S; Coughlin, M; Sugihara-Seki, M; Schmid-Schonbein, GW. “Mechanotransduction in Leukocyte Activation.” Biorheology, Vol. 44: pp. 221-249, 2007.
  • Pascarella, L; Lulic, D; Penn, AH; Alsaigh, TD; Lee, J; Shin, HY; Kapur, V; Bergan, JJ; Schmid-Schönbein, GW. “Mechanisms in Experimental Venous Valve Failure and Their Modification by MPFF.” European Journal of Vascular Surgery, Vol. 35: pp. 102-110, 2008.
  • Shin, HY; Simon, SI, Schmid-Schönbein, GW. “Fluid Shear-Induced Activation and Cleavage of CD18 During Pseudopod Retraction by Human Neutrophils.” Journal of Cellular Physiology, Vol. 214: pp. 528-536, 2008.
  • Chen, AY; Delano, FA; Valdez, SR; Ha, JN*; Shin, HY; Schmid-Schönbein, GW. “Receptor Cleavage Reduces the Fluid Shear Response in Neutrophils of the Spontaneously Hypertensive Rat.” American Journal of Physiology, Vol. 299: pp. C1441 – C1449, 2010.
  • Zhang, X; Hurng, J; Rateri, DL; Daugherty, A; Schmid- Schönbein, GW; Shin, HY. “Membrane Cholesterol Modulates the Fluid Shear Stress Response of Polymorphonuclear Leukocytes Via Its Effects on Membrane Fluidity.” American Journal of Physiology, vol. 301: pp. C451 – C460, 2011.
  • Zhang, X-Y; Shin, HY. Linking the Pathobiology of Hyperccholesterolemia with the Neutrophil Mechanotransduction.” in Kostner, G. (ed.) Lipoprotein/Book 2, Intech Publishing, Rijeka, Croatia, IN PRESS, 2012.
  • Shin, HY; Underwood, RM; Fannon, MA. “Fluid Pressure is a Magnitude-Dependent Modulator of Early Endothelial Tubulogenic Activity: Implications Related to a Potential Tissue Engineering Control Parameter.” Tissue Engineering, IN PRESS, 2012.
  • Zhang, X; Zhan, D; Shin HY. “Integrin Subtype-Dependent CD18 Cleavage Under Shear is Involved in Leukocyte-Platelet Binding.” Journal of Leukocyte Biology. In Revision (2012).
  • Shin, HY; Frechette, DM; Rohner, N; Zhang, X; Puleo, DA; Bjursten, LM. “Macrophage Superoxide Release Depends on the Pulse Amplitude of an Applied Pressure Regime: A Potential Factor at the Tissue-Implant Interface.” Journal of Tissue Engineering and Regenerative Medicine. In Revision (2012).