Daniel W. Pack, Ph.D.

Ashland Inc. Chair in Chemical Engineering

Research Areas: Engineering of advanced drug delivery systems with an emphasis on human gene therapy for the prevention control and treatment of disease

University of Kentucky, College of Engineering
Chemical and Materials Engineering - CME
161 FPAT
Lexington, KY 40506-0046
Phone: 859 257-0729
Email: dan.pack@uky.edu


Professional Preparation

1997 Ph.D., Chemical Engineering, California Institute of Technology, Pasadena
1990 B.S. (summa cum laude), Chemical Engineering, University of Illinois, Urbana-Champaign

Professional Appointments

2012-present   Ashland Inc. Chair in Chemical Engineering
2012-present   Professor of Chemical & Materials Engineering and Pharmaceutical Sciences, University of Kentucky
2009-2012       Professor of Chemical and Biomolecular Engineering, University of Illinois
2007-2012       Affiliate Faculty, Institute for Genomic Biology, University of Illinois
2006- 2012      Affiliate Faculty, Beckman Institute, University of Illinois
2005-2009       Associate Professor of Chemical and Biomolecular Engineering, University of Illinois
2004- 2012      Affiliate Faculty, Department of Bioengineering, University of Illinois, Urbana-Champaign
2003- 2012      Research Faculty, Center for Nanoscale Science and Technology, University of Illinois, Urbana-Champaign
2000- 2012      Biotechnology Center Faculty, University of Illinois, Urbana-Champaign
2000-2004       Faculty of Bioengineering, University of Illinois, Urbana-Champaign
1999-2005       Assistant Professor of Chemical and Biomolecular Engineering, University of Illinois, Urbana-Champaign
1996-1998       Post-Doctoral Research Fellow, Massachusetts Institute of Technology

Awards and Honors

2008                Xerox Award for Faculty Research, College of Engineering, University of Illinois, Urbana-Champaign
2007                Multi-Year Faculty Achievement Award, College of Engineering, University of Illinois, Urbana-Champaign
2007                Engineering Council Award for Excellence in Advising, University of Illinois, Urbana-Champaign
2006                Alumni Discretionary Award, College of Liberal Arts and Sciences, University of Illinois, Urbana-Champaign
2006                Engineering Council Award for Excellence in Advising, University of Illinois, Urbana-Champaign
2004-2005       Beckman Fellow, Center for Advanced Study, University of Illinois, Urbana-Champaign
2004                Controlled Release Society/Genencor Outstanding Consumer & Diversified Products Paper Award
2003-2006       3M Young Faculty Award
2003                Excellence in Teaching Award, School of Chemical Sciences, University of Illinois, Urbana-Champaign
2002-2007       Faculty Early Career Development (CAREER) Award, National Science Foundation
2000                Incomplete List of Teachers Ranked as Excellent by Their Students, Fall 2000, University of Illinois, Urbana-Champaign
2000                Excellence in Teaching Award, School of Chemical Sciences, University of Illinois, Urbana-Champaign
2000                Collins Scholar, Academy for Excellence in Engineering Education, University of Illinois, Urbana-Champaign
1997-1999       National Institutes of Health Post-doctoral Fellowship, Massachusetts Institute of Technology
1996                Distinguished Graduate Student Lectureship, California Institute of Technology
1995                Materials Research Society Graduate Student Award
1991-1994       Landau Fellowship, California Institute of Technology
1990                University Scholar, University of Illinois
1990                Senior Alumni Award (Chemical Engineering), University of Illinois

Selected Publications

REPRESENTATIVE PUBLICATIONS (58 total; h-index = 31) 

  • A.N. Ford Versypt, D.W. Pack and R.D. Braatz (2012) “Mathematical modeling of drug delivery
    from autocatalytically degradable PLGA microspheres—a review.” Journal of Controlled Release
    165, 29-37.
  • A. Barnard, P. Posocco, S. Pricl, M. Calderon, R. Haag, M.E. Hwang, V.W.T. Shum, D.W. Pack and
    D.K. Smith (2011) “Degradable self-assembling dendrons for gene delivery – experimental and
    theoretical insights into the barriers to cellular uptake.” Journal of the American Chemical Society
    133, 20288-20300.
  • Q. Xu, C.-H. Wang and D.W. Pack (2010) “Polymeric carriers for gene delivery: chitosan and
    poly(amidoamine) dendrimers.” Current Pharmaceutical Design 16, 2350-2368. PMCID:
    PMC3471158
  • J.D. Ramsey, H.N. Vu and D.W. Pack (2010) “A top-down approach for construction of hybrid
    polymer-virus gene delivery vectors.” Journal of Controlled Release 144, 39-45.
  • N.P. Gabrielson and D.W. Pack (2009) “Efficient polyethylenimine-mediated gene delivery proceeds
    via a caveolar pathway in HeLa cells.” Journal of Controlled Release 136, 54-61.
  • H. Hosseinkhani, M. Hosseinkhani, N.P. Gabrielson, D.W. Pack, A. Khademhosseini and H.
    Kobayashi (2008) “DNA nanoparticles encapsulated in 3-D tissue engineered scaffolds enhance
    osteogenic differentiation of mesenchymal stem cells.” Journal of Biomedical Materials Research
    Part A 85A, 47-60.
  • H.N. Vu, J.D. Ramsey and D.W. Pack (2008) “Engineering of a stable retroviral gene delivery vector
    by directed evolution.” Molecular Therapy 16, 308-314.
  • C. Berkland, E.J. Pollauf, C. Raman, R. Silverman, K. Kim and D.W. Pack (2007) “Macromolecule
    release from monodisperse PLG microspheres: control of release rates and investigation of release
    mechanism.” Journal of Pharmaceutical Science 96, 1176-1191.
  • C. Berkland, E.J. Pollauf, N.K. Varde, D.W. Pack and K. K. Kim (2007) “Monodisperse liquid-filled
    biodegradable microcapsules.” Pharmaceutical Research 24, 1007-1013.
  • N.P. Gabrielson and D.W. Pack (2006) “Acetylation of polyethylenimine enhances gene delivery via
    weakened polymer/DNA interactions.” Biomacromolecules 7, 2427-2435.
  • D.W. Pack, A.S. Hoffman, S. Pun and P. Stayton (2005) “Design and development of polymeric gene
    delivery vectors.” Nature Reviews Drug Discovery 4, 581-593.