Daniel W. Pack, Ph.D.

Ashland Inc. Chair in Chemical Engineering

Research Areas:

University of Kentucky, College of Engineering
Chemical and Materials Engineering - CME
161 FPAT
Lexington, KY 40506-0046
Phone: 859 257-0729
Email: dan.pack@uky.edu


Professional Preparation

1997 Ph.D., Chemical Engineering, California Institute of Technology, Pasadena
1990 B.S. (summa cum laude), Chemical Engineering, University of Illinois, Urbana-Champaign

Professional Appointments

2012-present   Ashland Inc. Chair in Chemical Engineering
2012-present   Professor of Chemical & Materials Engineering and Pharmaceutical Sciences, University of Kentucky
2009-2012       Professor of Chemical and Biomolecular Engineering, University of Illinois
2007-2012       Affiliate Faculty, Institute for Genomic Biology, University of Illinois
2006- 2012      Affiliate Faculty, Beckman Institute, University of Illinois
2005-2009       Associate Professor of Chemical and Biomolecular Engineering, University of Illinois
2004- 2012      Affiliate Faculty, Department of Bioengineering, University of Illinois, Urbana-Champaign
2003- 2012      Research Faculty, Center for Nanoscale Science and Technology, University of Illinois, Urbana-Champaign
2000- 2012      Biotechnology Center Faculty, University of Illinois, Urbana-Champaign
2000-2004       Faculty of Bioengineering, University of Illinois, Urbana-Champaign
1999-2005       Assistant Professor of Chemical and Biomolecular Engineering, University of Illinois, Urbana-Champaign
1996-1998       Post-Doctoral Research Fellow, Massachusetts Institute of Technology

Awards and Honors

2008                Xerox Award for Faculty Research, College of Engineering, University of Illinois, Urbana-Champaign
2007                Multi-Year Faculty Achievement Award, College of Engineering, University of Illinois, Urbana-Champaign
2007                Engineering Council Award for Excellence in Advising, University of Illinois, Urbana-Champaign
2006                Alumni Discretionary Award, College of Liberal Arts and Sciences, University of Illinois, Urbana-Champaign
2006                Engineering Council Award for Excellence in Advising, University of Illinois, Urbana-Champaign
2004-2005       Beckman Fellow, Center for Advanced Study, University of Illinois, Urbana-Champaign
2004                Controlled Release Society/Genencor Outstanding Consumer & Diversified Products Paper Award
2003-2006       3M Young Faculty Award
2003                Excellence in Teaching Award, School of Chemical Sciences, University of Illinois, Urbana-Champaign
2002-2007       Faculty Early Career Development (CAREER) Award, National Science Foundation
2000                Incomplete List of Teachers Ranked as Excellent by Their Students, Fall 2000, University of Illinois, Urbana-Champaign
2000                Excellence in Teaching Award, School of Chemical Sciences, University of Illinois, Urbana-Champaign
2000                Collins Scholar, Academy for Excellence in Engineering Education, University of Illinois, Urbana-Champaign
1997-1999       National Institutes of Health Post-doctoral Fellowship, Massachusetts Institute of Technology
1996                Distinguished Graduate Student Lectureship, California Institute of Technology
1995                Materials Research Society Graduate Student Award
1991-1994       Landau Fellowship, California Institute of Technology
1990                University Scholar, University of Illinois
1990                Senior Alumni Award (Chemical Engineering), University of Illinois

Publications

Peer-Reviewed Publications (h-index = 30)

  1. M. Kishida, A. Ford-Versypt, D.W. Pack and R.D. Braatz (2012) “Optimal control of 1D cellular uptake in tissue engineering.” submitted. 
  2. A.N. Ford Versypt, D.W. Pack and R.D. Braatz (2012) “Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres—a review.” in press.
  3. X. Zhu, D.W. Pack and R.D. Braatz (2012) “Modeling intravascular delivery from drug-eluting stents with biodurable coating: investigation of anisotropic vascular drug diffusivity and arterial drug distribution.” Computer Methods in Biomechanics and Biomedical Engineering, in press. PMCID: PMC3442148
  4. Q. Xu, C.-H. Wang and D.W. Pack (2012) “Monodisperse double-walled microspheres loaded with chitosan-p53 nanoparticles and doxorubicin for combined gene therapy and chemotherapy.” Journal of Controlled Release 163, 130-135.
  5. V.W.T. Shum, N.P. Gabrielson, M.L. Forrest and D.W. Pack (2012) “The effects of PVP(Fe(III)) catalyst on polymer molecular weight and gene delivery via biodegradable cross-linked polyethylenimine.” Pharmaceutical Research 29, 500-510. PMCID: PMC3465843
  6. A. Barnard, P. Posocco, S. Pricl, M. Calderon, R. Haag, M.E. Hwang, V.W.T. Shum, D.W. Pack and D.K. Smith (2011) “Degradable self-assembling dendrons for gene delivery – experimental and theoretical insights into the barriers to cellular uptake.” Journal of the American Chemical Society 133, 20288-20300.
  7. S.C. Wuang, K.G. Neoh, E.T. Kang, D.E. Leckband and D.W. Pack (2011) “Acid-sensitive magnetic nanoparticles as potential drug depots.” AIChE Journal 57, 1638-1645. PMCID: PMC3134249
  8. S. Jones, N. Gabrielson, C.-H. Wong, H.-F. Chow, D.W. Pack, P. Posocco, M. Fermeglia, S. Pricl, and D. Smith (2011) “Hydrophobically modified DNA binding dendrons – developing structure-activity relationships for DNA binding and gene transfection.” Molecular Pharmaceutics 8, 416-429. 
  9. D.M. Drake, R.K. Keswani and D.W. Pack (2010) “Effect of serum on transfection by polyethylenimine/virus-like particle hybrid gene delivery vectors.” Pharmaceutical Research 27, 2457-2465.
  10. Q. Xu, C.-H. Wang and D.W. Pack (2010) “Polymeric carriers for gene delivery: chitosan and poly(amidoamine) dendrimers.” Current Pharmaceutical Design 16, 2350-2368. PMCID: PMC3471158