Daniel W. Pack, Ph.D.

Ashland Inc. Chair in Chemical Engineering

Research Areas:

University of Kentucky, College of Engineering
Chemical and Materials Engineering - CME
161 FPAT
Lexington, KY 40506-0046
Phone: 859 257-0729
Email: dan.pack@uky.edu


Professional Preparation

1997 Ph.D., Chemical Engineering, California Institute of Technology, Pasadena
1990 B.S. (summa cum laude), Chemical Engineering, University of Illinois, Urbana-Champaign

Professional Appointments

2012-present   Ashland Inc. Chair in Chemical Engineering
2012-present   Professor of Chemical & Materials Engineering and Pharmaceutical Sciences, University of Kentucky
2009-2012       Professor of Chemical and Biomolecular Engineering, University of Illinois
2007-2012       Affiliate Faculty, Institute for Genomic Biology, University of Illinois
2006- 2012      Affiliate Faculty, Beckman Institute, University of Illinois
2005-2009       Associate Professor of Chemical and Biomolecular Engineering, University of Illinois
2004- 2012      Affiliate Faculty, Department of Bioengineering, University of Illinois, Urbana-Champaign
2003- 2012      Research Faculty, Center for Nanoscale Science and Technology, University of Illinois, Urbana-Champaign
2000- 2012      Biotechnology Center Faculty, University of Illinois, Urbana-Champaign
2000-2004       Faculty of Bioengineering, University of Illinois, Urbana-Champaign
1999-2005       Assistant Professor of Chemical and Biomolecular Engineering, University of Illinois, Urbana-Champaign
1996-1998       Post-Doctoral Research Fellow, Massachusetts Institute of Technology

Awards and Honors

2008                Xerox Award for Faculty Research, College of Engineering, University of Illinois, Urbana-Champaign
2007                Multi-Year Faculty Achievement Award, College of Engineering, University of Illinois, Urbana-Champaign
2007                Engineering Council Award for Excellence in Advising, University of Illinois, Urbana-Champaign
2006                Alumni Discretionary Award, College of Liberal Arts and Sciences, University of Illinois, Urbana-Champaign
2006                Engineering Council Award for Excellence in Advising, University of Illinois, Urbana-Champaign
2004-2005       Beckman Fellow, Center for Advanced Study, University of Illinois, Urbana-Champaign
2004                Controlled Release Society/Genencor Outstanding Consumer & Diversified Products Paper Award
2003-2006       3M Young Faculty Award
2003                Excellence in Teaching Award, School of Chemical Sciences, University of Illinois, Urbana-Champaign
2002-2007       Faculty Early Career Development (CAREER) Award, National Science Foundation
2000                Incomplete List of Teachers Ranked as Excellent by Their Students, Fall 2000, University of Illinois, Urbana-Champaign
2000                Excellence in Teaching Award, School of Chemical Sciences, University of Illinois, Urbana-Champaign
2000                Collins Scholar, Academy for Excellence in Engineering Education, University of Illinois, Urbana-Champaign
1997-1999       National Institutes of Health Post-doctoral Fellowship, Massachusetts Institute of Technology
1996                Distinguished Graduate Student Lectureship, California Institute of Technology
1995                Materials Research Society Graduate Student Award
1991-1994       Landau Fellowship, California Institute of Technology
1990                University Scholar, University of Illinois
1990                Senior Alumni Award (Chemical Engineering), University of Illinois

Selected Publications

REPRESENTATIVE PUBLICATIONS (58 total; h-index = 31) 

  • A.N. Ford Versypt, D.W. Pack and R.D. Braatz (2012) “Mathematical modeling of drug delivery
    from autocatalytically degradable PLGA microspheres—a review.” Journal of Controlled Release
    165, 29-37.

  • A. Barnard, P. Posocco, S. Pricl, M. Calderon, R. Haag, M.E. Hwang, V.W.T. Shum, D.W. Pack and
    D.K. Smith (2011) “Degradable self-assembling dendrons for gene delivery – experimental and
    theoretical insights into the barriers to cellular uptake.” Journal of the American Chemical Society
    133, 20288-20300.

  • Q. Xu, C.-H. Wang and D.W. Pack (2010) “Polymeric carriers for gene delivery: chitosan and
    poly(amidoamine) dendrimers.” Current Pharmaceutical Design 16, 2350-2368. PMCID:
    PMC3471158

  • J.D. Ramsey, H.N. Vu and D.W. Pack (2010) “A top-down approach for construction of hybrid
    polymer-virus gene delivery vectors.” Journal of Controlled Release 144, 39-45.

  • N.P. Gabrielson and D.W. Pack (2009) “Efficient polyethylenimine-mediated gene delivery proceeds
    via a caveolar pathway in HeLa cells.” Journal of Controlled Release 136, 54-61.

  • H. Hosseinkhani, M. Hosseinkhani, N.P. Gabrielson, D.W. Pack, A. Khademhosseini and H.
    Kobayashi (2008) “DNA nanoparticles encapsulated in 3-D tissue engineered scaffolds enhance
    osteogenic differentiation of mesenchymal stem cells.” Journal of Biomedical Materials Research
    Part A 85A, 47-60.

  • H.N. Vu, J.D. Ramsey and D.W. Pack (2008) “Engineering of a stable retroviral gene delivery vector
    by directed evolution.” Molecular Therapy 16, 308-314.

  • C. Berkland, E.J. Pollauf, C. Raman, R. Silverman, K. Kim and D.W. Pack (2007) “Macromolecule
    release from monodisperse PLG microspheres: control of release rates and investigation of release
    mechanism.” Journal of Pharmaceutical Science 96, 1176-1191.

  • C. Berkland, E.J. Pollauf, N.K. Varde, D.W. Pack and K. K. Kim (2007) “Monodisperse liquid-filled
    biodegradable microcapsules.” Pharmaceutical Research 24, 1007-1013.

  • N.P. Gabrielson and D.W. Pack (2006) “Acetylation of polyethylenimine enhances gene delivery via
    weakened polymer/DNA interactions.” Biomacromolecules 7, 2427-2435.

  • D.W. Pack, A.S. Hoffman, S. Pun and P. Stayton (2005) “Design and development of polymeric gene
    delivery vectors.” Nature Reviews Drug Discovery 4, 581-593.