Compensating Interfering Effects for Localized Surface-Plasmon Resonance Sensors

Mentors: Hastings and Wei

Surface-plasmon resonance (SPR) sensing has become a mainstay of drug discovery, and there are many emerging applications in food safety, environmental monitoring, and medical diagnostics.[1, 2]  However, interfering effects such as non-specific binding and changes in solution refractive index limit SPR sensing in complex media.  Drs. Hastings and Wei are developing surface plasmon resonance sensors that compensate for these effects by exciting multiple surface-plasmon modes on thin metal films or metallic nanostructures.[3-14]  Thanks to NSF support, they recently demonstrated that U-shaped gold nanostructures with three localized resonances can compensate for both non-specific protein binding and index changes in liquid volumes less than a cubic micron.[15]  This project offers an excellent platform for an REU experience because the instrumentation and methodologies are in place, and the REU student can immediately focus novel systems and translational applications.  In Theme 1, the students will evaluate sensing architectures involving new metal nanostructure geometries and their functionalization for protein recognition.  In Theme 2, the students will focus on evaluating these sensors’ performance for detection and bio-interaction analysis in the presence of interfering effects.



[1]            A. P. F. Turner, “Biosensors: sense and sensibility,” Chemical Society Reviews, vol. 42, pp. 3184-3196, April 2013.

[2]            H. Šípová and J. Homola, “Surface plasmon resonance sensing of nucleic acids: A review,” Analytica Chimica Acta, vol. 773, pp. 9-23, April 2013.

[3]            N. Nehru, E. U. Donev, G. M. Huda, L. L. Yu, Y. N. Wei, and J. T. Hastings, “Differentiating surface and bulk interactions using localized surface plasmon resonances of gold nanorods,” Optics Express, vol. 20, pp. 6905-6914, Mar 2012.

[4]            N. Nehru, L. Yu, Y. Wei, and J. T. Hastings, “Reference Compensated Localized Surface Plasmon Resonance based Sensor,” in IEEE Nano: 12th International Conference on Nanotechnology, Birmingham, UK, 2012.

[5]            P. D. Keathley and J. T. Hastings, “Nano-gap-Enhanced Surface Plasmon Resonance Sensors,” Plasmonics, vol. 7, pp. 59-69, Mar 2012.

[6]            J. Guo, P. D. Keathley, and J. T. Hastings, “Dual-mode surface-plasmon-resonance sensors using angular interrogation,” Optics Letters, vol. 33, pp. 512-514, Mar 2008.

[7]            P. D. Keathley and J. T. Hastings, “Optical properties of sputtered fluorinated ethylene propylene and its application to surface-plasmon resonance sensor fabrication,” Journal of Vacuum Science & Technology B, vol. 26, pp. 2473-2477, Nov 2008.

[8]            J. T. Hastings, J. Guo, P. D. Keathley, P. B. Kumaresh, Y. Wei, S. Law, et al., “Optimal self-referenced sensing using long- and short- range surface plasmons,” Opt. Express, vol. 15, pp. 17661-17672, Dec 2007.

[9]            J. T. Hastings, N. Nehru, and M. D. Bresin, “Focused electron-beam induced deposition of plasmonic nanostructures from aqueous solutions,” in Proc. SPIE 8613, Advanced Fabrication Technologies for Micro/Nano Optics and Photonics VI, San Francisco, CA, 2013, pp. 861306-861306-7.

[10]         N. Nehru and J. T. Hastings, “Optical sensing characteristics of nanostructures supporting multiple localized surface plasmon resonances,” in Proc. SPIE 8594, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications X, San Francisco, CA, 2013, pp. 859405-859405-6.

[11]         L. Webb and J. T. Hastings, “Silver in dual-mode Surface-Plasmon Resonance sensors,” in IEEE Southeastcon, 2009, pp. 13-17.

[12]         J. T. Hastings, “Optimizing Surface-Plasmon Resonance Sensors for Limit of Detection Based on a Cramer Rao Bound,” IEEE Sensors Journal, vol. 8, pp. 170-175, Feb. 2008.

[13]         M. Florea, J. T. Hastings, and C. Adeola, “Wavelength shift analysis techniques and methods for dual mode surface plasmon resonance sensors,” in IEEE Southeastcon, 2008, pp. 432-435.

[14]         J. T. Hastings, “Spectral peak-shift estimation with wavelength dependent sources and detectors,” IEEE Transactions on Signal Processing, vol. 56, pp. 5269-5272, Oct 2008.

[15]         N. Nehru, L. Yu, Y. Wei, and J. T. Hastings, “Using U-Shaped Localized Surface Plasmon Resonance Sensors to Compensate for Nonspecific Interactions,” Ieee Transactions on Nanotechnology, vol. 13, pp. 55-61, Jan 2014.